Guides, research, and insights
125 articlesGLP-1s show promise for fatty liver, but what about cirrhosis? Evidence, safety concerns, and why advanced liver disease requires special consideration.
Can cancer survivors safely use Ozempic or Wegovy? Evidence on GLP-1s after cancer treatment, weight management, and special considerations for cancer history.
GLP-1 medications reduce inflammation markers like CRP and IL-6. How this may explain benefits for heart disease, arthritis, and autoimmune conditions.
What we know (and don't know) about Ozempic, Wegovy, and tirzepatide in adults over 75. Trial exclusions, frailty concerns, and when GLP-1s may still make sense.
Can you use Ozempic or Wegovy after gastric sleeve or bypass? Evidence on weight regain treatment, safety considerations, and which post-bariatric patients are candidates.
How Ozempic and Wegovy work during perimenopause. Addressing hormonal weight gain, interactions with HRT, and what the research shows for women 40-55.
FDA-approved GLP-1 medications for adolescents 12+. STEP TEENS trial data, safety considerations, and what the AAP recommends for childhood obesity treatment.
Complete analysis of GLP-1 clinical trials in adolescents. STEP TEENS results, liraglutide pediatric data, and ongoing tirzepatide studies in children and teens.
Complete guide to GLP-1 medications during and after menopause. HRT compatibility, targeting visceral fat, bone health monitoring, and cardiovascular benefits for postmenopausal wo
Evidence-based guide to Ozempic, Wegovy, and other GLP-1s for seniors. Clinical trial data on adults 65+, muscle loss prevention, and special considerations from the SELECT and FLO
Can you use Ozempic or tirzepatide while preserving muscle? Body composition data, cutting phase strategies, and what bodybuilders need to know about GLP-1s.
How Ozempic and Wegovy affect athletic performance, muscle mass, endurance, and recovery. WADA status, professional athlete considerations, and sports-specific guidance.
An honest look at the unanswered questions about GLP-1 medications. What the long-term data is missing and what we're still learning.
Practical nutrition guidance for Ozempic, Wegovy, and Mounjaro. What to eat, what to avoid, and how to maximize results while minimizing side effects.
Comparing GLP-1 medications to bariatric surgery. Outcomes, reversibility, costs, and how to decide which approach is right for you.
How to travel with Ozempic, Wegovy, or Mounjaro. TSA rules, temperature storage, and international considerations.
Separating fact from fiction on the most viral GLP-1 claims. What the science actually says about common Ozempic myths.
Protein requirements while on Ozempic, Wegovy, or Mounjaro. How much to eat, best sources, and strategies for when appetite is low.
10-15% of people don't respond well to GLP-1 medications. The science behind non-response and what to try next.
How to exercise while on Ozempic, Wegovy, or Mounjaro. Why resistance training is essential and how to optimize your workouts.
Fake Ozempic and Wegovy are circulating. How to identify counterfeit GLP-1 medications and protect yourself from dangerous fakes.
An honest analysis of GLP-1 medication costs vs benefits. What the health economics research says about value.
Emerging research on semaglutide for cocaine and stimulant use disorders. What the science shows and what trials are underway.
Can Ozempic help binge eating disorder? The research on GLP-1 medications for BED and compulsive eating patterns.
GLP-1 medications aren't for everyone. Contraindications, cautions, and conditions that may make these drugs inappropriate.
Practical, evidence-based strategies for managing nausea, constipation, and other common GLP-1 side effects. What works and what doesn't.
Head-to-head comparison of the major GLP-1 medications. Differences in weight loss, mechanism, dosing, side effects, and cost.
What's coming after Ozempic and Mounjaro? Retatrutide, orforglipron, and the next wave of obesity medications in clinical trials.
A realistic timeline of your GLP-1 journey. What happens month 1, month 3, month 6, and beyond. Setting proper expectations.
Strategies for getting GLP-1 medications covered by insurance, manufacturer savings programs, and alternative options when coverage fails.
The truth about compounded GLP-1 medications. What we know about safety, quality concerns, and how to minimize risk.
Food noise is the constant mental chatter about eating. Here's what it means, why some people have it, and how GLP-1 medications turn down the volume.
When Oprah and other celebrities started talking openly about weight loss medications, the conversation changed. The cultural shift from secret shame to mainstream acceptance.
Some people report reduced enjoyment of food, hobbies, and life on GLP-1 medications. What does the science say about this concern?
A major JAMA Psychiatry study found 50-56% lower alcohol use disorder among GLP-1 patients. The science behind why Ozempic makes people drink less.
People report their urge to shop has vanished on GLP-1 medications. Why dopamine-driven retail therapy may be the latest 'addiction' these drugs affect.
People are reporting they quit smoking on Ozempic without trying. The science behind GLP-1s and nicotine addiction, plus active clinical trials.
Researchers are calling GLP-1 medications a potential paradigm shift for addiction treatment. What the 12+ clinical trials mean for the future of treating compulsive behaviors.
Reports of gambling urges disappearing on GLP-1 medications. The dopamine connection, viral stories, and what researchers think is happening.
A 2024 study found 44% lower cannabis use among patients on GLP-1 medications. What the research shows about marijuana, dopamine, and these drugs.
Tirzepatide becomes the first medication ever approved to treat obstructive sleep apnea. What the SURMOUNT-OSA trial showed and what it means for 30 million Americans.
How semaglutide and tirzepatide are helping women with PCOS. The connection between insulin resistance, weight loss, and hormonal balance.
The FLOW trial was stopped early because semaglutide worked so well for kidney disease. What the data shows and what it means for millions with CKD.
Semaglutide dramatically improved symptoms and quality of life in heart failure patients. What the STEP-HFpEF trial means for millions living with HFpEF.
Semaglutide shows remarkable results for MASH (fatty liver disease). What the ESSENCE trial found and why FDA granted Breakthrough Therapy designation.
What the research shows about semaglutide and NAION (nonarteritic anterior ischemic optic neuropathy). The JAMA study, FDA FAERS data, risk factors, and what you should watch for.
The facts on semaglutide, tirzepatide and thyroid cancer risk. Understanding the FDA Black Box Warning, rodent studies vs human data, and who should not take GLP-1 medications.
What happens when you stop Ozempic or Zepbound? The STEP-1 extension data on weight regain, tapering strategies, and when you actually need to stop permanently.
The facts on semaglutide, tirzepatide and pancreatitis risk. Symptoms to watch for, who's at higher risk, and why you must stop permanently if it occurs.
Why rapid weight loss from semaglutide and tirzepatide increases gallstone risk. Symptoms to watch for, when to pause treatment, and whether you can restart after gallbladder surge
Complete analysis of Eli Lilly's retatrutide (LY3437943): 28.7% weight loss in TRIUMPH trials, how triple agonism works, side effects including dysesthesia, and 2027 approval timel
On December 20, 2024, the FDA approved Zepbound as the first-ever medication for obstructive sleep apnea. Here's what the SURMOUNT-OSA trial actually showed.
What happens when you stop semaglutide or tirzepatide? We analyze the STEP 1 extension, SURMOUNT-4, and real-world data on weight regain and prevention strategies.
Everything you need to know about tirzepatide (Mounjaro/Zepbound). How it works, dosing, what to expect, and why it's different from semaglutide.
Why do Ozempic and Wegovy cause rotten egg burps? The science of delayed gastric emptying, hydrogen sulfide, and evidence-based relief strategies.
Head-to-head comparison of semaglutide and tirzepatide. Efficacy, side effects, cost, and who each medication works best for.
Everything you need to know about semaglutide. How it works, what to expect, dosing, side effects, and results from clinical trials.
Complete analysis of the SELECT trial that proved semaglutide reduces heart attacks, strokes, and cardiovascular death in people without diabetes. 17,604 patients, 20% risk reducti
Ozempic requires a valid prescription in the US. Here's why, what the legal requirements are, and how to access it legitimately.
Men on semaglutide report their penis 'got bigger.' We talked to Yale urologists and reviewed the research. Here's what the evidence actually shows.
Rapid GLP-1 weight loss can cause facial volume loss, sagging skin, and premature aging. Here's what dermatologists and plastic surgeons say—with data.
Thousands report strange, vivid dreams on semaglutide. Shopping with Clint Eastwood, robbing museums with celebrities. Here's the neuroscience and what Novo Nordisk says.
Randomized trial data confirms semaglutide reduces alcohol consumption. The neuroscience of why GLP-1 drugs decrease drinking—verified with sources.
Eli Lilly's orforglipron: 14.7% weight loss in a daily pill, no fasting required, projected $200-350/month pricing. ATTAIN trial results and 2026 approval timeline.
Oral semaglutide (Rybelsus) has 0.4-1% bioavailability vs. 89% for injectable. Here's the complete pharmacokinetic comparison and what it means for efficacy.
Novo Nordisk has filed 111+ lawsuits against compounding pharmacies and telehealth companies. Track every case, outcome, and what it means for compounded semaglutide.
Retatrutide delivers 28.7% weight loss in Phase 3. Amycretin hits 22%. Orforglipron offers needle-free daily pill. Complete trial data on what's coming next.
GLP-1 delivery methods compared. Needles vs pills vs drops. Pros, cons, and which format fits your lifestyle.
The exact process from quiz to delivery. How telehealth GLP-1 prescriptions work, what to expect, and how long it takes.
Complete guide on when to pause or stop semaglutide and tirzepatide. Covers pre-surgery protocols, pregnancy planning, adverse events, weight plateaus, and what happens when you st
Weight loss stopped on Ozempic? Research shows plateaus typically occur around 60-68 weeks. Here's why it happens and what to do about it.
Research shows GLP-1 medications can increase testosterone levels in men with obesity by 18% on average. Here's the complete data on hormonal effects.
Why does food taste different on semaglutide? New research shows GLP-1 drugs actually change taste bud gene expression and brain response to sweetness.
Complete guide to switching from semaglutide to tirzepatide or between GLP-1 providers: when to switch, dose conversion, avoiding gaps, and what to expect.
Can Ozempic help you quit smoking? We analyze the Annals of Internal Medicine study, active clinical trials, and the science behind GLP-1s and nicotine addiction.
Tirzepatide dramatically reduced sleep apnea severity in obese patients, potentially offering an alternative to CPAP. NEJM results show up to 63% AHI reduction.
GLP-1 users report reduced compulsive shopping. No studies exist, but the dopamine science is intriguing. We separate anecdotes from theory.
The raw ingredient for a month of Ozempic costs under $50. So why does a prescription cost $1,000+? Breaking down the GLP-1 pricing chain with sources.
Complete guide to next-gen GLP-1 drugs: CagriSema, Amycretin, Survodutide, VK2735, and more. Efficacy rankings, mechanisms, timelines, and how they compare to current medications.
Lixisenatide stopped motor symptom progression in early Parkinson's patients. Here's what the NEJM trial found and what's coming next.
Can semaglutide reduce opioid cravings? Penn State researchers found a 40% reduction in cravings in early trials. Here's the data from NIH-funded studies.
Comprehensive analysis of body composition data from STEP, SURMOUNT, and SURPASS trials. What DXA and MRI studies reveal about semaglutide and tirzepatide effects on lean mass.
Semaglutide received FDA approval for MASH in August 2025—the second drug ever approved for fatty liver disease. Phase 3 trial data, tirzepatide pipeline, and what it means.
Complete guide to managing nausea on semaglutide and tirzepatide: why it happens, how long it lasts, foods that help, medications like Zofran, and when to call your doctor.
The landmark FLOW trial showed semaglutide reduced major kidney events and death in diabetic kidney disease. Published in NEJM, stopped early for efficacy.
Navigate GLP-1 insurance in 2025: Medicare/Medicaid coverage by state, commercial plan restrictions, prior auth strategies, appeal tactics, and manufacturer savings programs up to
Complete guide to injecting semaglutide and tirzepatide: best injection sites, rotation patterns, preparation steps, and techniques for reducing pain and anxiety.
New data suggests GLP-1 drugs may reduce inflammation markers and autoimmune disease risk. Here's what the research shows for rheumatoid arthritis, psoriasis, and IBD.
Is GLP-1 hair loss real? We reviewed every FAERS analysis, cohort study, and dermatology paper. Here's what the data actually shows.
GLP-1 medications may help gout by lowering uric acid levels. The obesity-gout connection, research on semaglutide and uric acid, and what patients report.
Users report GLP-1s curb gambling and shopping urges. We analyze the anecdotal reports, dopamine science, and why no clinical trials exist yet.
Exenatide and liraglutide trials for alcohol and cocaine showed mixed results. Why researchers think semaglutide's different pharmacology could change outcomes.
What does science actually say about 'Ozempic babies'? Complete analysis of GLP-1 fertility research in PCOS, weight loss effects, birth control interactions, and pregnancy safety
Complete chronological history of GLP-1 medication FDA approvals. From Byetta (2005) to today's expanded indications for cardiovascular protection, sleep apnea, and kidney disease.
Complete guide to GLP-1 medication interactions with insulin, sulfonylureas, birth control, levothyroxine, warfarin, and alcohol. Based on FDA labels and 2025 ADA guidelines.
FDA and EMA investigations, FAERS data, WHO database analysis, and controlled studies on semaglutide and mental health. The complete picture with sources.
The EVOKE trial of semaglutide for Alzheimer's didn't show benefit. But observational data suggests protection. Here's what we know about GLP-1s and brain health.
How to evaluate compounding pharmacies for semaglutide and tirzepatide. 503A vs 503B explained, PCAB accreditation, COA verification, FDA warning signs, and 15 questions to ask bef
The FDA declared semaglutide and tirzepatide shortages resolved. Here's what's still legal for compounding, the clinical difference exception, pending lawsuits, and what it means f
Semaglutide reduced cocaine self-administration by 26% in rats and cocaine-seeking by 62%. We analyze the University of Gothenburg study and $2.7M UTHealth trial.
How GLP-1 weight loss medications may improve chronic pain conditions. The obesity-pain connection, anti-inflammatory effects, and what patients report.
A study of 680,000+ patients found semaglutide users were 44-60% less likely to develop cannabis use disorder. We break down the Wang et al. 2024 findings.
GLP-1 receptors in the VTA, nucleus accumbens, and prefrontal cortex may explain why these drugs affect cravings. A visual guide to the neuroscience.
Weight loss reduces AFib burden significantly. How GLP-1 medications may help atrial fibrillation through weight loss and beyond.
If GLP-1s dampen the reward system, could they reduce pleasure from everything—not just food and drugs? What we know about anhedonia risk.
The EVOKE trials testing semaglutide for Alzheimer's disease failed their primary endpoints in November 2025. Here's what the data actually showed and what it means.
The first randomized controlled trial of semaglutide for alcohol use disorder is here. We break down exactly what the February 2025 JAMA Psychiatry study found.
Can you drink alcohol on Ozempic or Zepbound? The science on GLP-1 alcohol interactions: hypoglycemia risk, slower metabolism, reduced cravings, and liver protection research.
Your complete prep list before starting GLP-1 treatment. Documents, supplies, questions to ask, and how to set yourself up for success.
How to spot sketchy GLP-1 telehealth providers. Red flags, warning signs, and what legitimate providers do differently.
Practical solutions for GLP-1 nausea. What causes it, when it improves, and 8 strategies that actually work.
The quick primer on GLP-1 medications. What they are, how they work, and whether they're right for you. No medical jargon, just facts.
GLP-1 eligibility explained. BMI requirements, medical conditions, and common myths busted. Find out if you qualify.
Real GLP-1 prices from real providers. What you'll actually pay for semaglutide and tirzepatide in 2025, including brand-name and compounded options.
Practical fixes for GLP-1-related constipation. Why it happens and what to do about it.
fMRI brain imaging reveals how GLP-1 medications reduce food cravings and intrusive food thoughts. Primary research from Nature Medicine and clinical trials.
Day-by-day guide to your first week on GLP-1 medication. What's normal, what's not, and how to set yourself up for success.
The FDA sent 50+ warning letters to GLP-1 compounders in September 2025. We've compiled every letter with analysis of what triggered enforcement.
Complete analysis of the EVOKE and EVOKE+ Phase 3 trials. Semaglutide didn't slow Alzheimer's progression, but biomarker data and observational studies suggest prevention potential
FDA testing found compounded semaglutide potency ranging 42-170% of labeled dose. FAERS reports 442 adverse events. Here's the complete safety comparison.
Independent lab testing of compounded semaglutide found products ranging from 42% to 170% of labeled potency. Here's what the data reveals about quality variation.
FDA testing data, Novo Nordisk analyses, and independent assays reveal wide potency variation in compounded semaglutide—from 0% to over 120% of labeled strength.
Which celebrities have actually admitted to using Ozempic, Wegovy, or Mounjaro? We tracked down the direct quotes — no speculation, just confirmed statements.
Understand the FDA's 503A and 503B compounding designations. Learn how they affect your semaglutide and tirzepatide prescriptions, quality standards, and what certifications to loo
Emerging evidence that GLP-1 weight loss may improve psoriasis severity. The obesity-inflammation-psoriasis connection and what patients are reporting.
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